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Non‐transcriptional interactions of Hox proteins: Inventory, facts, and future directions
Author(s) -
Rezsohazy René
Publication year - 2014
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.24060
Subject(s) - hox gene , biology , homeobox , transcription factor , dna replication , transcription (linguistics) , gene , translation (biology) , microbiology and biotechnology , transcriptional regulation , genetics , dna , cell fate determination , computational biology , messenger rna , linguistics , philosophy
Hox proteins are conserved homeodomain transcription factors involved in the control of embryo patterning, organ development, and cell differentiation during animal development and adult life. Although recognizably active in gene regulation, accumulating reports support that Hox proteins are also active in controlling other molecular processes like mRNA translation, DNA repair, initiation of DNA replication, and possibly modulation of signal transduction. Here we review experimental evidence as well as databases entries indicative of non‐transcriptional activities of Hox proteins. Developmental Dynamics 243:117–131, 2014 . © 2013 Wiley Periodicals, Inc.