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RGMa and RGMb expression pattern during chicken development suggest unexpected roles for these repulsive guidance molecules in notochord formation, somitogenesis, and myogenesis
Author(s) -
Jorge Erika Cristina,
Ahmed Mohi U.,
Bothe Ingo,
Coutinho Luiz Lehmman,
Dietrich Susanne
Publication year - 2012
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.23889
Subject(s) - somitogenesis , neural tube , biology , somite , myogenesis , neural crest , notochord , microbiology and biotechnology , netrin , axon guidance , embryo , neuroscience , embryogenesis , myocyte , axon
Background: Repulsive guidance molecules (RGM) are high‐affinity ligands for the Netrin receptor Neogenin, and they are crucial for nervous system development including neural tube closure; neuronal and neural crest cell differentiation and axon guidance. Recent studies implicated RGM molecules in bone morphogenetic protein signaling, which regulates a variety of developmental processes. Moreover, a role for RGMc in iron metabolism has been established. This suggests that RGM molecules may play important roles in non‐neural tissues. Results: To explore which tissues and processed may be regulated by RGM molecules, we systematically investigated the expression of RGMa and RGMb , the only RGM molecules currently known for avians, in the chicken embryo. Conclusions: Our study suggests so far unknown roles of RGM molecules in notochord, somite and skeletal muscle development. Developmental Dynamics, 2012. © 2012 Wiley Periodicals, Inc.