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In vivo notch reactivation in differentiating cochlear hair cells induces sox2 and prox1 expression but does not disrupt hair cell maturation
Author(s) -
Liu Zhiyong,
Owen Thomas,
Fang Jie,
Srinivasan R. Sathish,
Zuo Jian
Publication year - 2012
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.23863
Subject(s) - organ of corti , biology , hair cell , sox2 , microbiology and biotechnology , cochlea , anatomy , transcription factor , gene , genetics
COVER PHOTOGRAPH: Lineage tracing of Prox1 expressing inner ear cochlear cells in Prox1CreEGFP/+; Rosa26‐EYFPloxp/+ mice at P23. All cochlear hair cells are labeled with calbindin in red. EYFP in green historically records the cochlear cells experiencing Prox1 expression during the development, which include hair cells and supporting cells (both inside and outside the organ of Corti). From Liu et al., Developmental Dynamics 241:684–696, 2012.