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Tol2 gene trap integrations in the zebrafish amyloid precursor protein genes appa and aplp2 reveal accumulation of secreted APP at the embryonic veins
Author(s) -
Liao HsinKai,
Wang Ying,
Noack Watt Kristin E.,
Wen Qin,
Breitbach Justin,
Kemmet Chelsy K.,
Clark Karl J.,
Ekker Stephen C.,
Essner Jeffrey J.,
McGrail Maura
Publication year - 2012
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.23829
Subject(s) - moesin , biology , green fluorescent protein , zebrafish , microbiology and biotechnology , anatomy , embryo , hemangioblast , embryonic stem cell , gene , transgene , ezrin , cell , genetics , cytoskeleton
Abstract COVER PHOTOGRAPH: Confocal image of live 36 hpf double transgenic appais22Gt; Tg(flk1:moesin‐gfp)is1 embryo. The image shows accumulation of appaRFP fusion proteins specifically at the veinous vessels in the head and anterior region of the trunk, including the midcerebral and common cardinal veins. Arteries and veins are visualized by expression of moesin:GFP throughout all endothelial cells of the vasculature. From Liao et al., Developmental Dynamics 241:415–425, 2012.