Premium
ILF‐3 is a regulator of the neural plate border marker Zic1 in chick embryos
Author(s) -
Fishwick K. J.,
Kim E.,
Bronner M. E.
Publication year - 2012
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.23809
Subject(s) - biology , neural crest , neural plate , enhancer , sox10 , microbiology and biotechnology , embryo , transcription factor , neural cell , neural fold , gene , cell type , anatomy , genetics , cell
Background : The neural crest is a multipotent cell type unique to the vertebrate lineage and capable of differentiating into a large number of varied cell types, including ganglia of the peripheral nervous system, cartilage, and glia. An early step in neural crest specification occurs at the neural plate border, a region defined by the overlap of transcription factors of the Zic, Msx , and Pax families. Results : Here we identify a novel chick gene with close homology to double‐stranded RNA‐binding protein Interleukin enhancer binding factor 3 ( ILF‐3 ) in other species. Our results show that chick Ilf‐3 is required for proper expression of the transcription factor, Zic‐1 , at the neural plate border. Conclusion : We have identified a novel chick gene and show it has a role in the correct specification of Zic‐1 at the neural plate border. Developmental Dynamics 241:1325–1332, 2012. © 2012 Wiley Periodicals, Inc.