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Tissue interaction is required for glenoid fossa development during temporomandibular joint formation
Author(s) -
Wang Ying,
Liu Chao,
Rohr Joseph,
Liu Hongbing,
He Fenglei,
Yu Jian,
Sun Cheng,
Li Lu,
Gu Shuping,
Chen YiPing
Publication year - 2011
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.22748
Subject(s) - fossa , condyle , temporomandibular joint , endochondral ossification , cartilage , ossification , intramembranous ossification , anatomy , biology , orthodontics , medicine
The mammalian temporomandibular joint (TMJ) develops from two distinct mesenchymal condensations that grow toward each other and ossify through different mechanisms, with the glenoid fossa undergoing intramembranous ossification while the condyle being endochondral in origin. In this study, we used various genetically modified mouse models to investigate tissue interaction between the condyle and glenoid fossa during TMJ formation in mice. We report that either absence or dislocation of the condyle results in an arrested glenoid fossa development. In both cases, glenoid fossa development was initiated, but failed to sustain, and became regressed subsequently. However, condyle development appears to be independent upon the presence of the forming glenoid fossa. In addition, we show that substitution of condyle by Meckel's cartilage is able to sustain glenoid fossa development. These observations suggest that proper signals from the developing condyle or Meckel's cartilage are required to sustain the glenoid fossa development. Developmental Dynamics 240:2466–2473, 2011. © 2011 Wiley‐Liss, Inc.