z-logo
Premium
Generating neuronal diversity in the Drosophila central nervous system
Author(s) -
Lin Suewei,
Lee Tzumin
Publication year - 2012
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.22739
Subject(s) - biology , neuroscience , nervous system , neural development , diversification (marketing strategy) , drosophila (subgenus) , drosophila melanogaster , neuron , neurogenesis , embryonic stem cell , central nervous system , process (computing) , progenitor cell , evolutionary biology , genetics , stem cell , gene , computer science , operating system , marketing , business
Generating diverse neurons in the central nervous system involves three major steps. First, heterogeneous neural progenitors are specified by positional cues at early embryonic stages. Second, neural progenitors sequentially produce neurons or intermediate precursors that acquire different temporal identities based on their birth‐order. Third, sister neurons produced during asymmetrical terminal mitoses are given distinct fates. Determining the molecular mechanisms underlying each of these three steps of cellular diversification will unravel brain development and evolution. Drosophila has a relatively simple and tractable CNS, and previous studies on Drosophila CNS development have greatly advanced our understanding of neuron fate specification. Here we review those studies and discuss how the lessons we have learned from fly teach us the process of neuronal diversification in general. Developmental Dynamics 241:57–68, 2012. © 2011 Wiley Periodicals, Inc.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here