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The roles of the cadherins Fat and Dachsous in planar polarity specification in Drosophila
Author(s) -
Thomas Chloe,
Strutt David
Publication year - 2012
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.22736
Subject(s) - polarity (international relations) , biology , cadherin , drosophila (subgenus) , microbiology and biotechnology , cell polarity , planar , genetics , gene , cell , computer graphics (images) , computer science
Planar polarity is generated through the activity of two groups of proteins, the “core” system and the Fat (Ft)/Dachsous (Ds) system. Although both are conserved from insects to mammals, vertebrate studies into planar polarity have primarily focussed on core planar polarity proteins and have only recently branched into the study of the Ft/Ds system. In Drosophila , however, years of detailed analysis have started to elucidate some of the mechanisms by which Ft/Ds signalling might set up polarity across a tissue, and how this may impact upon core protein‐mediated planar polarity. In this review, we discuss the major findings, models, and controversies that have emerged from Drosophila research into the Ft/Ds system, and indicate some areas for further investigation. Developmental Dynamics 241:27–39, 2012. © 2011 Wiley Periodicals, Inc.