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The identification of different endothelial cell populations within the mouse proepicardium
Author(s) -
Cossette Stephanie,
Misra Ravi
Publication year - 2011
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.22724
Subject(s) - biology , sinus venosus , vasculogenesis , population , embryonic stem cell , microbiology and biotechnology , embryogenesis , coronary sinus , embryo , anatomy , medicine , genetics , stem cell , progenitor cell , demography , sociology , gene
The proepicardium is a transient embryonic structure that is a source of precursors of the epicardium, coronary smooth muscle cells, and may be a source of coronary endothelial cells (EC). To better understand proepicardium development a systematic analysis of EC appearance was performed. Multiple marker analysis showed that EC are present in the mouse proepicardium at embryonic day (E) 9.0 through E9.75. Distinct populations of EC were found that were associated with the liver bud, and the sinus venosus, as well as a population that do not appear to be associated with either of these structures. There was a temporal increase in the number of EC and temporal changes in the distribution of EC within the different populations during PE development. These findings indicate that EC exist in the proepicardium before coronary vasculogenesis, and support a model in which there is a heterogeneous origin for EC in the proepicardium. Developmental Dynamics 240:2344–2353, 2011. © 2011 Wiley‐Liss, Inc.