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Discrete regulatory regions control early and late expression of D‐Pax2 during external sensory organ development
Author(s) -
Johnson Seth A.,
Harmon Katharine J.,
Smiley Sarah G.,
Still Frances M.,
Kavaler Joshua
Publication year - 2011
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.22672
Subject(s) - biology , sensory system , transcription factor , enhancer , microbiology and biotechnology , regulation of gene expression , expression (computer science) , cellular differentiation , cell fate determination , cell lineage , gene , neuroscience , genetics , computer science , programming language
The transcription factor D‐Pax2 is required for the correct differentiation of several cell types in Drosophila sensory systems. While the regulation of its expression in the developing eye has been well studied, little is known about the mechanisms by which the dynamic pattern of D‐Pax2 expression in the external sensory organs is achieved. Here we demonstrate that early activation of D‐Pax2 in the sensory organ lineage and its maintenance in the trichogen and thecogen cells are governed by separate enhancers. Furthermore, the initial activation is controlled in part by proneural proteins whereas the later maintenance expression is regulated by a positive feedback loop. Developmental Dynamics 240:1769–1778, 2011. © 2011 Wiley‐Liss, Inc.