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Spatiotemporal changes in cell adhesiveness during vertebrate limb morphogenesis
Author(s) -
Wada Naoyuki
Publication year - 2011
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.22552
Subject(s) - mesenchyme , biology , blastema , limb bud , morphogenesis , limb development , microbiology and biotechnology , zone of polarizing activity , mesenchymal stem cell , anatomy , regeneration (biology) , cell , cartilage , genetics , embryogenesis , embryo , ectoderm , gene
Abstract During vertebrate limb development, various molecules are expressed in the presumptive limb field or the limb bud in a spatiotemporal‐specific manner. The combination of these molecules regulates cellular properties that affect limb initiation and its morphogenesis, especially cartilage formation. Cell adhesiveness of the limb mesenchyme is a key factor in the regulation of cell distribution. Differential adhesiveness of mesenchymal cells is first observed between cells in the presumptive limb field and flank region, and the adhesiveness of the cells in the limb field is higher than that of cells in the flank region. In the limb bud, the adhesiveness of mesenchymal cells shows spatiotemporal difference, which reflects the positional identity of the cells. Position‐dependent cell adhesiveness is also observed in blastema cells of the regenerating limb. Therefore, local changes in cell adhesiveness are observed during limb development and regeneration, suggesting significant roles for cell adhesiveness in limb morphogenesis. Developmental Dynamics 240:969–978, 2011. © 2011 Wiley‐Liss, Inc.