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Vertebrate intestinal endoderm development
Author(s) -
Spence Jason R.,
Lauf Ryan,
Shroyer Noah F.
Publication year - 2011
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.22540
Subject(s) - endoderm , biology , gastrulation , morphogenesis , microbiology and biotechnology , vertebrate , anatomy , foregut , intestinal villus , organogenesis , embryogenesis , embryo , embryonic stem cell , small intestine , endocrinology , genetics , gene
The endoderm gives rise to the lining of the esophagus, stomach and intestines, as well as associated organs. To generate a functional intestine, a series of highly orchestrated developmental processes must occur. In this review, we attempt to cover major events during intestinal development from gastrulation to birth, including endoderm formation, gut tube growth and patterning, intestinal morphogenesis, epithelial reorganization, villus emergence, as well as proliferation and cytodifferentiation. Our discussion includes morphological and anatomical changes during intestinal development as well as molecular mechanisms regulating these processes. Developmental Dynamics 240:501–520, 2011. © 2011 Wiley‐Liss, Inc.