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Far From Solved: A Perspective on What We Know About Early Mechanisms of Left–Right Asymmetry
Author(s) -
Vandenberg Laura N.,
Levin Michael
Publication year - 2010
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.22510
Subject(s) - biology , blastomere , body plan , embryo , cleavage (geology) , anatomy , asymmetry , microbiology and biotechnology , evolutionary biology , zoology , embryogenesis , paleontology , physics , quantum mechanics , fracture (geology)
The frog embryo knows its left from its right as early as the first cell cleavage. Here, at the 2‐cell stage, one blastomere was injected with the fluorescent dye Oregon Green, while the other blastomere was injected with Rhodamine. The resulting pattern in the mature tadpole reveals the concordance of the first cell division with the midplane of the bilaterally‐symmetric vertebrate body‐plan. From Vandenberg and Levin et al., Developmental Dynamics 239:3131–3146, 2010.