Premium
Expression patterns of ShcD and Shc family adaptor proteins during mouse embryonic development
Author(s) -
Hawley Steve P.,
Wills Melanie K.B.,
Rabalski Adam J.,
Bendall Andrew J.,
Jones Nina
Publication year - 2011
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.22506
Subject(s) - biology , microbiology and biotechnology , neural crest , signal transducing adaptor protein , embryonic stem cell , mitosis , embryo , embryogenesis , signal transduction , genetics , gene
The Src homology and collagen (Shc) proteins function as molecular adaptors in signaling pathways mediated by a variety of cell surface receptors. Of the four mammalian Shc proteins, ShcD is the least characterized. To this end, ShcD expression was documented and compared to that of other Shc family proteins. In the developing mouse embryo, expression of ShcD overlaps with that of other Shc proteins in the central nervous system, with specific distribution in post‐mitotic neurons. In addition, robust ShcD expression is seen within differentiated epithelial cells of several organs, as well as in skeletal and cardiac muscle, and various tissues of neural crest origin. Interestingly, all Shc family members are expressed in hypertrophic chondrocytes, the first report of Shc protein expression in the developing skeleton. The unique tissue distribution patterns of Shc proteins likely contribute to their complex tissue‐specific signaling functions during embryogenesis. Developmental Dynamics, 2011. © 2010 Wiley‐Liss, Inc.