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Regulation of ocellar specification and size by twin of eyeless and homothorax
Author(s) -
Brockmann Anette,
DomínguezCejudo María A.,
Amore Gabriele,
Casares Fernando
Publication year - 2011
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.22494
Subject(s) - biology , simple eye in invertebrates , pax6 , krüppel , gene regulatory network , gene , gene expression , regulation of gene expression , genetics , mechanism (biology) , microbiology and biotechnology , drosophila melanogaster , neuroscience , anatomy , transcription factor , philosophy , epistemology
The retinal determination gene network (RDGN) constitutes a paradigm of a gene network controlling organ specification and growth. In this study, we probed the RDGN in the Drosophila ocelli, a set of simple eyes located on the fly's dorsal head, by studying the expression, regulation, and function of toy , hth , eya , and so , members of the Pax6, Meis, Eya, and Six gene families. Our results highlight the role of the pax6 gene toy , together with the hh signaling pathway, in the initiation of eya and so expression; the engagement of eya and so in a feedback loop necessary for their full expression; and the interplay between hh signaling and hth as a mechanism of organ size control, as general regulatory steps in the specification of visual organs. Developmental Dynamics, 2011. © 2010 Wiley‐Liss, Inc.