Premium
Developmental expression of Bdnf, Ntf4/5, and TrkB in the mouse peripheral taste system
Author(s) -
Huang Tao,
Krimm Robin F.
Publication year - 2010
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.22412
Subject(s) - tropomyosin receptor kinase b , geniculate ganglion , brain derived neurotrophic factor , neurotrophic factors , biology , neurotrophin , taste , medicine , endocrinology , neuroscience , microbiology and biotechnology , receptor , genetics , pathology , alternative medicine , palsy
Abstract Brain‐derived neurotrophic factor (BDNF), neurotrophin‐4 (NT4), and their TrkB receptor regulate taste system development. To determine where and when gustatory neurons come in contact with these important factors, temporospatial expression patterns of Bdnf, Ntf4/5, and TrkB in the peripheral taste system were examined using RT‐PCR. In the lingual epithelium, Ntf4/5 mRNA expression was higher than that of Bdnf at embryonic day 12.5 (E12.5), and the expression of both factors decreased afterwards. However, Ntf4/5 expression decreased at an earlier age than Bdnf. Bdnf and Ntf4/5 are expressed in equal amounts at E12.5 in geniculate ganglion, but Bdnf expression increased from E14.5 to birth, whereas Ntf4/5 expression decreased. These findings indicate that NT4 functions at early embryonic stages and is derived from different sources than Bdnf . TrkB expression in the geniculate ganglion is robust throughout development and is not a limiting factor for neurotrophin function in this system. Developmental Dynamics 239:2637–2646, 2010. © 2010 Wiley‐Liss, Inc.