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Mature hair follicles generated from dissociated cells: A universal mechanism of folliculoneogenesis
Author(s) -
Zheng Ying,
Nace Arben,
Chen Wei,
Watkins Krystal,
Sergott Luke,
Homan Ying,
Vandeberg John L.,
Breen Matthew,
Stenn Kurt
Publication year - 2010
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.22398
Subject(s) - biology , hair follicle , follicle , opossum , microbiology and biotechnology , morphogenesis , mechanism (biology) , monodelphis domestica , anatomy , endocrinology , genetics , gene , philosophy , epistemology
The hair follicle is considered to be a model system for studying organogenesis. In our initial study using mouse cells (Zheng et al., 2005) we found that new hair follicle formation always starts from an epithelial platform: the epidermal cells aggregate, the aggregates encyst, and from the periphery of the cysts, centrifugally, hair buds, pegs, and follicles form. In this report, we extend our initial study to four distantly related mammals: opossum, rat, dog and human. We find that in these four species, plus mouse, the most trichogenic cells are found in the earliest stages of hair follicle development and that the cellular mechanism of new hair follicle formation starting from dissociated cells is largely the same. These studies suggest that there is essentially one way by which dissociated mammalian skin cells form a new hair follicle in vivo and that this mechanism has been highly conserved. Developmental Dynamics 239:2619–2626, 2010. © 2010 Wiley‐Liss, Inc.