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Regional expression of the ADAMs in developing chicken cochlea
Author(s) -
Yan Xin,
Lin Juntang,
Wang Hong,
Markus Annett,
Wree Andreas,
Rolfs Arndt,
Luo Jiankai
Publication year - 2010
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.22360
Subject(s) - spiral ganglion , cochlea , biology , ganglion , cadherin , adam10 , in situ hybridization , microbiology and biotechnology , anatomy , inner ear , disintegrin , metalloproteinase , gene expression , cell , matrix metalloproteinase , gene , biochemistry , genetics
The expression patterns of five members of the ADAM (a disintegrin and metalloprotease) family including ADAM9, ADAM10, ADAM17, ADAM22, and ADAM23 were analyzed in different anatomical structures of the developing chicken cochlea by in situ hybridization and immunohistochemistry. Results show that ADAM9, ADAM10, and ADAM17 are widely expressed in the sensory epithelium of the basilar papilla, by homogene cells, spindle‐shaped cells, and acoustic ganglion cells, and in the tegmentum vasculosum, each with a different pattern. ADAM22 expression is restricted to spindle‐shaped cells and acoustic ganglion cells, while ADAM23 is prominently expressed by hair cells and acoustic ganglion cells. Furthermore, ADAM10 protein is coexpressed with several members of the classic cadherins, including cadherin‐7, N‐cadherin, and R‐cadherin in distinct anatomical regions of the cochlea except for acoustic ganglion cells. The expression of the ADAMs in the developing cochlea suggests a contribution of the ADAMs to the development of distinct cochlear structures. Developmental Dynamics 239:2256–2265, 2010. © 2010 Wiley‐Liss, Inc.