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Developmental atlas of the early first trimester human embryo
Author(s) -
Yamada Shigehito,
Samtani Rajeev R.,
Lee Elaine S.,
Lockett Elizabeth,
Uwabe Chigako,
Shiota Kohei,
Anderson Stasia A.,
Lo Cecilia W.
Publication year - 2010
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.22316
Subject(s) - biology , embryo , atlas (anatomy) , organogenesis , sagittal plane , anatomy , high resolution , magnetic resonance imaging , human protein atlas , computational biology , bioinformatics , microbiology and biotechnology , genetics , radiology , medicine , remote sensing , geology , gene , protein expression
Rapid advances in medical imaging are facilitating the clinical assessment of first-trimester human embryos at increasingly earlier stages. To obtain data on early human development, we used magnetic resonance (MR) imaging and episcopic fluorescence capture (EFIC) to acquire digital images of human embryos spanning the time of dynamic tissue remodeling and organogenesis (Carnegie stages 13 to 23). These imaging data sets are readily resectioned digitally in arbitrary planes, suitable for rapid high-resolution three-dimensional (3D) observation. Using these imaging datasets, a web-accessible digital Human Embryo Atlas (http://apps.devbio.pitt.edu/humanatlas/) was created containing serial 2D images of human embryos in three standard histological planes: sagittal, frontal, and transverse. In addition, annotations and 3D reconstructions were generated for visualizing different anatomical structures. Overall, this Human Embryo Atlas is a unique resource that provides morphologic data of human developmental anatomy that can accelerate basic research investigations into developmental mechanisms that underlie human congenital anomalies.