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Expression patterns of sulfatase genes in the developing mouse embryo
Author(s) -
Ratzka Andreas,
Mundlos Stefan,
Vortkamp Andrea
Publication year - 2010
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.22294
Subject(s) - biology , sulfatase , in situ hybridization , embryo , gene , microbiology and biotechnology , genetics , embryonic stem cell , gene expression , regulation of gene expression , enzyme , biochemistry
Mammalian sulfatase enzymes participate in various processes, such as hormone regulation, lysosomal degradation and modulation of several signaling pathways. The sulfatase gene family consists of 14 members in mice and 17 in humans. Mutations of at least eight members are associated with human disorders, with main disease manifestations in the nervous system and skeleton. Despite their biological significance, little is known about their expression during embryonic development, especially for the more recently discovered gene family members. By in situ hybridization, we compared the expression patterns of nine sulfatases: ArsB , ArsG , ArsI , ArsJ , Galns , Gns , Ids , Sulf1 , and Sulf2 in midgestation mouse embryos. Of interest, overlapping expression domains of several sulfatases could be detected in the developing central nervous system, eye, skeleton, and inner organs. Moreover, novel expression patterns for ArsG in choroid plexus, ArsI in hypertrophic chondrocytes and ArsJ in joints were identified. Developmental Dynamics 239:1779–1788, 2010. © 2010 Wiley‐Liss, Inc.