Fusion of uniluminal vascular spheroids: A model for assembly of blood vessels | Zendy

Fleming Paul A. | Zendy; Argraves W. Scott | Zendy; Gentile Carmine | Zendy; Neagu Adrian | Zendy; Forgacs Gabor | Zendy; Drake Christopher J. | Zendy

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Fusion of uniluminal vascular spheroids: A model for assembly of blood vessels

Author(s) -

Fleming Paul A.,

Argraves W. Scott,

Gentile Carmine,

Neagu Adrian,

Forgacs Gabor,

Drake Christopher J.

Publication year - 2010

Publication title -

developmental dynamics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.634

H-Index - 141

eISSN - 1097-0177

pISSN - 1058-8388

DOI - 10.1002/dvdy.22257

Subject(s) - spheroid , biology , lumen (anatomy) , anatomy , endothelium , blood vessel , microbiology and biotechnology , fusion , actin , biophysics , vascular smooth muscle , smooth muscle , in vitro , endocrinology , biochemistry , linguistics , philosophy

Blood vessel formation via vascular fusion. When placed into hanging drop culture, five uniluminal vascular spheroids fuse to form a single, larger diameter spheroid with an outer layer of smooth muscle alpha actin positive cells (red) and an inner PECAM‐1 positive endothelium (green) surrounding a large central lumen. From Fleming et al., Developmental Dynamics 239:398–406, 2010.

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