Premium
Fusion of uniluminal vascular spheroids: A model for assembly of blood vessels
Author(s) -
Fleming Paul A.,
Argraves W. Scott,
Gentile Carmine,
Neagu Adrian,
Forgacs Gabor,
Drake Christopher J.
Publication year - 2010
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.22257
Subject(s) - spheroid , biology , lumen (anatomy) , anatomy , endothelium , blood vessel , microbiology and biotechnology , fusion , actin , biophysics , vascular smooth muscle , smooth muscle , in vitro , endocrinology , biochemistry , linguistics , philosophy
Blood vessel formation via vascular fusion. When placed into hanging drop culture, five uniluminal vascular spheroids fuse to form a single, larger diameter spheroid with an outer layer of smooth muscle alpha actin positive cells (red) and an inner PECAM‐1 positive endothelium (green) surrounding a large central lumen. From Fleming et al., Developmental Dynamics 239:398–406, 2010.