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Caenorhabditis elegans : A new model organism for studies of axon regeneration
Author(s) -
GhoshRoy Anindya,
Chisholm Andrew D.
Publication year - 2010
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.22253
Subject(s) - biology , caenorhabditis elegans , model organism , regeneration (biology) , axon , microbiology and biotechnology , organism , computational biology , genetics , gene
Axonal regeneration in Caenorhabditis elegans was first reported five years ago. Individual green fluorescent protein‐labeled axons can be severed using laser microsurgery and their regrowth followed in vivo. Several neuron types display robust regrowth after injury, including motor and sensory neurons. The small size and transparency of C. elegans make possible large‐scale genetic and pharmacological screens for regeneration phenotypes. Developmental Dynamics 239:1460–1464, 2010. © 2010 Wiley‐Liss, Inc.