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Recent advances in understanding the molecular mechanisms regulating C. elegans transcription
Author(s) -
Gaudet Jeb,
McGhee James D.
Publication year - 2010
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.22246
Subject(s) - biology , caenorhabditis elegans , transcription factor , histone , transcription (linguistics) , chromatin , nucleosome , cell fate determination , microbiology and biotechnology , promoter , genetics , general transcription factor , computational biology , gene , gene expression , linguistics , philosophy
We review recent studies that have advanced our understanding of the molecular mechanisms regulating transcription in the nematode C. elegans . Topics covered include: (i) general properties of C. elegans promoters; (ii) transcription factors and transcription factor combinations involved in cell fate specification and cell differentiation; (iii) new roles for general transcription factors; (iv) nucleosome positioning in C. elegans “chromatin”; and (v) some characteristics of histone variants and histone modifications and their possible roles in controlling C. elegans transcription. Developmental Dynamics 239:1388–1404, 2010. © 2010 Wiley‐Liss, Inc.