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Understanding the role of asymmetric cell division in cancer using C. elegans
Author(s) -
Hyenne Vincent,
Chartier Nicolas T.,
Labbé JeanClaude
Publication year - 2010
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.22237
Subject(s) - biology , caenorhabditis elegans , asymmetric cell division , cell division , carcinogenesis , microbiology and biotechnology , cell , embryo , developmental biology , cell fate determination , stem cell , computational biology , genetics , cancer , gene , transcription factor
Asymmetric cell division is an important process to generate cell diversity and maintain tissue homeostasis. Recent evidence suggests that this process may also be crucial to prevent tumor formation. In the past 30 years, the embryo of the nematode Caenorhabditis elegans has proven to be a very powerful model to study the molecular and cellular basis of asymmetric cell division. Understanding this process in Caenorhabditis elegans may thus lead to a better understanding of stem cell function and tumorigenesis in humans. Developmental Dynamics 239:1378–1387, 2010. © 2010 Wiley‐Liss, Inc.