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Developmental biomarkers of aging in Caenorhabditis elegans
Author(s) -
Pincus Zachary,
Slack Frank J.
Publication year - 2010
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.22224
Subject(s) - biology , caenorhabditis elegans , genetics , gene
The developmental process of the nematode Caenorhabditis elegans is famously invariant; however, these animals have surprisingly variable lifespans, even in extremely homogenous environments. Inter‐individual differences in muscle‐function decline, accumulation of lipofuscin in the gut, internal growth of food bacteria, and ability to mobilize heat‐shock responses all appear to be predictive of a nematode's remaining lifespan; whether these are causal, or mere correlates of individual decline and death, has yet to be determined. Moreover, few “upstream” causes of inter‐individual variability have been identified. It may be the case that variability in lifespan is entirely due to stochastic damage accumulation; alternately, perhaps such variability has a developmental origin and/or genes involved in developmental canalization also act to buffer phenotypic heterogeneity later in life. We review these two hypotheses with an eye toward whether they can be experimentally differentiated. Developmental Dynamics 239:1306–1314, 2010. © 2010 Wiley‐Liss, Inc.