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The role of cell cycle in retinal development: Cyclin‐dependent kinase inhibitors co‐ordinate cell‐cycle inhibition, cell‐fate determination and differentiation in the developing retina †
Author(s) -
Bilitou Aikaterini,
Ohnuma Shinichi
Publication year - 2010
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.22223
Subject(s) - biology , cell fate determination , cell cycle , microbiology and biotechnology , retina , cell , cell growth , cellular differentiation , cell cycle checkpoint , neuroscience , genetics , transcription factor , gene
Abstract The mature retina is formed through multi‐step developmental processes, including eye field specification, optic vesicle evagination, and cell‐fate determination. Co‐ordination of these developmental events with cell‐proliferative activity is essential to achieve formation of proper retinal structure and function. In particular, the molecular and cellular dynamics of the final cell cycle significantly influence the identity that a cell acquires, since cell fate is largely determined at the final cell cycle for the production of postmitotic cells. This review summarizes our current understanding of the cellular mechanisms that underlie the co‐ordination of cell‐cycle and cell‐fate determination, and also describes a molecular role of cyclin‐dependent kinase inhibitors (CDKIs) as co‐ordinators of cell‐cycle arrest, cell‐fate determination and differentiation. Developmental Dynamics 239:727–736, 2010. © 2010 Wiley‐Liss, Inc.