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The trimeric G protein Go inflicts a double impact on axin in the Wnt/frizzled signaling pathway
Author(s) -
EggerAdam Diane,
Katanaev Vladimir L.
Publication year - 2010
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.22209
Subject(s) - wnt signaling pathway , biology , frizzled , morphogen , microbiology and biotechnology , wnt3a , appendage , signal transduction , lrp5 , genetics , anatomy , gene
COVER PHOTOGRAPH: Signaling by the Wingless morphogen (a member of the Wnt family of secreted glycoproteins) is required for the proper development of appendages in Drosophila . Overexpression of Axin, a negative regulator of Wnt signaling, leads to severe defects in Drosophila wing growth and patterning (the affected wing is shown in a green pseudocolor, compared to a wild‐type wing in pink). The inhibitory activity of Axin can be suppressed by co‐expression of the GTP‐binding protein Gαo, leading to a partial rescue in wing development (yellow). Gαo physically binds the RGS domain of Axin and recruits Axin it to the plasma membrane, antagonizing the Axin‐based destruction complex. From Egger‐Adam and Katanaev, Developmental Dynamics 239:168–183, 2010. © 2009 Wiley‐Liss, Inc.