Premium
Role of bone morphogenetic proteins on cochlear hair cell formation: Analyses of Noggin and Bmp2 mutant mice
Author(s) -
Hwang Chan Ho,
Guo Dayong,
Harris Marie A.,
Howard Omar,
Mishina Yuji,
Gan Lin,
Harris Stephen E.,
Wu Doris K.
Publication year - 2010
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.22200
Subject(s) - noggin , organ of corti , bone morphogenetic protein , biology , bone morphogenetic protein 2 , hair cell , microbiology and biotechnology , conditional gene knockout , cochlea , inner ear , anatomy , endocrinology , medicine , genetics , phenotype , gene , in vitro
The mammalian organ of Corti of the inner ear is a highly sophisticated sensory end organ responsible for detecting sound. Noggin is a secreted glycoprotein, which antagonizes bone morphogenetic proteins 2 and 4 (Bmp2 and Bmp4). The lack of this antagonist causes increased rows of inner and outer hair cells in the organ of Corti. In mice, Bmp2 is expressed transiently in nascent cochlear hair cells. To investigate whether Noggin normally modulates the levels of Bmp2 for hair cell formation, we deleted Bmp2 in the cochlear hair cells using two cre strains, Foxg1 cre /+ and Gfi1 cre /+ . Bmp2 conditional knockout cochleae generated using these two cre strains show normal hair cells. Furthermore, Gfi1 cre /+ ; Bmp2 lox /− mice are viable and have largely normal hearing. The combined results of Noggin and Bmp2 mutants suggest that Noggin is likely to regulate other Bmps in the cochlea such as Bmp4. Developmental Dynamics 239:505–513, 2010. Published 2010 Wiley‐Liss, Inc.