Wnt modulators in the biotech pipeline | Zendy

Rey JeanPhilippe | Zendy; Ellies Debra L. | Zendy

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Wnt modulators in the biotech pipeline

Author(s) -

Rey JeanPhilippe,

Ellies Debra L.

Publication year - 2010

Publication title -

developmental dynamics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.634

H-Index - 141

eISSN - 1097-0177

pISSN - 1058-8388

DOI - 10.1002/dvdy.22181

Subject(s) - wnt signaling pathway , biology , proteomics , microbiology and biotechnology , receptor , signal transduction , computational biology , genetics , bioinformatics , gene

The purpose of this review is to provide a better understanding for the LRP co‐receptor‐mediated Wnt pathway signaling. Using proteomics, we have also subdivided the LRP receptor family into six sub‐families, encompassing the twelve family members. This review includes a discussion of proteins containing a cystine‐knot protein motif (i.e., Sclerostin, Dan, Sostdc1, Vwf, Norrin, Pdgf, Mucin) and discusses how this motif plays a role in mediating Wnt signaling through interactions with LRP. Developmental Dynamics 239:102–114, 2010. © 2009 Wiley‐Liss, Inc.

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