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Platelet‐derived growth factor is involved in the differentiation of second heart field‐derived cardiac structures in chicken embryos
Author(s) -
Bax Noortje A.M.,
LieVenema Heleen,
VicenteSteijn Rebecca,
Bleyl Steven B.,
Van Den Akker Nynke M.S.,
Maas Saskia,
Poelmann Robert E.,
Gittenbergerde Groot Adriana C.
Publication year - 2009
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.22073
Subject(s) - colocalization , platelet derived growth factor receptor , biology , receptor , platelet derived growth factor , growth factor , heart development , microbiology and biotechnology , medicine , embryo , endocrinology , anatomy , biochemistry , embryonic stem cell , gene
For the establishment of a fully functional septated heart, addition of myocardium from second heart field‐derived structures is important. Platelet‐derived growth factors (PDGFs) are known for their role in cardiovascular development. In this study, we aim to elucidate this role of PDGF‐A, PDGF‐C, and their receptor PDGFR‐α. We analyzed the expression patterns of PDGF‐A, ‐C, and their receptor PDGFR‐α during avian heart development. A spatiotemporal pattern of ligands was seen with colocalization of the PDGFR‐α. This was found in second heart field‐derived myocardium as well as the proepicardial organ (PEO) and epicardium. Mechanical inhibition of epicardial outgrowth as well as chemical disturbance of PDGFR‐α support a functional role of the ligands and the receptor in cardiac development. Developmental Dynamics 238:2658–2669, 2009. © 2009 Wiley‐Liss, Inc.