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Wnt to build a tube: Contributions of Wnt signaling to epithelial tubulogenesis
Author(s) -
Miller Rachel K.,
McCrea Pierre D.
Publication year - 2010
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.22059
Subject(s) - wnt signaling pathway , biology , morphogenesis , microbiology and biotechnology , epithelium , organ system , gastrointestinal tract , signal transduction , excretory system , beta catenin , anatomy , pathology , gene , genetics , medicine , biochemistry , disease
Epithelial tubes are crucial to the function of organ systems including the cardiovascular system, pulmonary system, gastrointestinal tract, reproductive organ systems, excretory system, and auditory system. Using a variety of animal model systems, recent studies have substantiated the role of Wnt signaling via the canonical/β‐catenin‐mediated trajectory, the non‐canonical Wnt trajectories, or both, in forming epithelial tubular tissues. This review focuses on the involvement of the Wnt pathways in the induction, specification, proliferation, and morphogenesis involved in tubulogenesis within tissues including the lungs, kidneys, ears, mammary glands, gut, and heart. The ultimate goal is to describe the developmental processes forming the various tubulogenic organ systems to determine the relationships between these processes. Developmental Dynamics 239:77–93, 2010. © 2009 Wiley‐Liss, Inc.