Premium
Development of the neuromuscular system during asexual propagation in an invertebrate chordate
Author(s) -
Tiozzo Stefano,
Murray Maureen,
Degnan Bernard M.,
De Tomaso Anthony W.,
Croll Roger P.
Publication year - 2009
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.22023
Subject(s) - chordate , biology , myogenesis , regeneration (biology) , model system , germline , anatomy , evolutionary biology , nervous system , vertebrate , neuroscience , microbiology and biotechnology , gene , computational biology , genetics , skeletal muscle
Botryllus schlosseri is a colonial ascidian, and the closest relative to vertebrates that can completely regenerate its entire body, including all somatic and germline tissues, using an asexual developmental pathway called blastogenesis. This regenerative potential exhibited by Botryllus and other colonial ascidians does not exist in any other chordate and makes B. schlosseri a promising model to investigate the cellular and molecular basis of regeneration. In this report, we describe postembryonic myogenesis and characterized the development of the neural system during blastogenic development. α‐Tubulin immunoreactivity revealed a high correlation with previous studies on the motor nervous system. The pattern of the serotoninergic system in the adult reflects that observed in solitary ascidians, but in early blastogenesis suggests a morphogenic role of this monoamine. In summary, this study provides the morphological framework to dissect the mechanisms underlying the ability to regenerate entire organ systems as an adult in a chordate model. Developmental Dynamics 238:2081–2094, 2009. © 2009 Wiley‐Liss, Inc.