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Regulation of Wnt/β‐catenin signaling by protein kinases
Author(s) -
Verheyen Esther M.,
Gottardi Cara J.
Publication year - 2010
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.22019
Subject(s) - wnt signaling pathway , biology , kinase , microbiology and biotechnology , signal transduction , catenin , protein serine threonine kinases , protein kinase a
The Wnt/β‐catenin signaling pathway plays essential roles during development and adult tissue homeostasis. Inappropriate activation of the pathway can result in a variety of malignancies. Protein kinases have emerged as key regulators at multiple steps of the Wnt pathway. In this review, we present a synthesis covering the latest information on how Wnt signaling is regulated by diverse protein kinases. Developmental Dynamics 239:34–44, 2010. © 2009 Wiley‐Liss, Inc.