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Role of Wnt signaling in the biology of the periodontium
Author(s) -
Rooker Scott M.,
Liu Bo,
Helms Jill A.
Publication year - 2010
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.22003
Subject(s) - biology , wnt signaling pathway , periodontium , microbiology and biotechnology , physiology , signal transduction , zoology , dentistry , medicine
Continuously erupting teeth have associated with them a continuously regenerating periodontal ligament, but the factors that control this amazing regenerative potential are unknown. We used genetic strategies to show that the periodontal ligament arises from the cranial neural crest. Despite their histological similarity, the periodontal ligament of continuously erupting incisor teeth differs dramatically from the periodontal ligament of molar teeth. The most notable difference was in the distribution of Wnt responsive cells in the incisor periodontal ligament, which coincided with regions of periodontal ligament cell proliferation. We discuss these findings in the context of dental tissue regeneration. Developmental Dynamics 239:140–147, 2010. © 2009 Wiley‐Liss, Inc.

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