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Molecular mechanisms of mechanosensing in muscle development
Author(s) -
Jani Klodiana,
Schöck Frieder
Publication year - 2009
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.21972
Subject(s) - biology , microbiology and biotechnology , function (biology) , integrin , myocyte , neuroscience , anatomy , genetics , receptor
Abstract Mechanical forces are crucial to muscle development and function, but the mechanisms by which forces are sensed and transduced remain elusive. Evidence implicates the sarcolemmal lattice of integrin adhesion and the Z‐disk components of the contractile machinery in such processes. These mechanosensory devices report changes in force to other cellular compartments by self‐remodeling. Here we explore how their structural and functional properties integrate to regulate muscle development and maintenance. Developmental Dynamics 238:1526–1534, 2009. © 2009 Wiley‐Liss, Inc.