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Expression of stem cell pluripotency factors during regeneration in newts
Author(s) -
Maki Nobuyasu,
SuetsuguMaki Rinako,
Tarui Hiroshi,
Agata Kiyokazu,
Del RioTsonis Katia,
Tsonis Panagiotis A.
Publication year - 2009
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.21959
Subject(s) - biology , regeneration (biology) , reprogramming , blastema , microbiology and biotechnology , stem cell , cell , anatomy , genetics
In this study, we present data indicating that mammalian stem cell pluripotency‐inducing factors are expressed during lens and limb regeneration in newts. The apparent expression even in intact tissues and the ensued regulation during regeneration raises the possibility that these factors might regulate tissue‐specific reprogramming and regeneration. Furthermore, these factors should enable us to understand the similarities and differences between animal regeneration in the newt and stem cell strategies in mammals. Developmental Dynamics 238:1613–1616, 2009. © 2009 Wiley‐Liss, Inc.