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Xenopus pancreas development
Author(s) -
Pearl Esther J.,
Bilogan Cassandra K.,
Mukhi Sandeep,
Brown Donald D.,
Horb Marko E.
Publication year - 2009
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.21935
Subject(s) - xenopus , biology , pancreas , endoderm , gastrulation , context (archaeology) , organogenesis , microbiology and biotechnology , pdx1 , computational biology , embryogenesis , embryo , endocrinology , genetics , islet , cellular differentiation , diabetes mellitus , paleontology , gene
Understanding how the pancreas develops is vital to finding new treatments for a range of pancreatic diseases, including diabetes and pancreatic cancer. Xenopus is a relatively new model organism for the elucidation of pancreas development, and has already made contributions to the field. Recent studies have shown benefits of using Xenopus for understanding both early patterning and lineage specification aspects of pancreas organogenesis. This review focuses specifically on Xenopus pancreas development, and covers events from the end of gastrulation, when regional specification of the endoderm is occurring, right through metamorphosis, when the mature pancreas is fully formed. We have attempted to cover pancreas development in Xenopus comprehensively enough to assist newcomers to the field and also to enable those studying pancreas development in other model organisms to better place the results from Xenopus research into the context of the field in general and their studies specifically. Developmental Dynamics 238:1271–1286, 2009. © 2009 Wiley‐Liss, Inc.