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Fibroblast growth factor expression during skeletal fracture healing in mice
Author(s) -
Schmid Gregory J.,
Kobayashi Chikashi,
Sandell Linda J.,
Ornitz David M.
Publication year - 2009
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.21882
Subject(s) - fibroblast growth factor , endochondral ossification , biology , fibroblast growth factor receptor , bone healing , microbiology and biotechnology , endocrinology , receptor , medicine , cartilage , anatomy , genetics
Fibroblast growth factors (FGFs) are important signaling molecules that regulate many stages of endochondral bone development. During the healing of a skeletal fracture, several features of endochondral bone development are reactivated. To better understand the role of FGFs in skeletal fracture healing, we quantitatively evaluated the temporal expression patterns of Fgfs , Fgf receptors ( Fgfrs ), and molecular markers of bone development over a 14‐day period following long bone fracture in a mouse model. These studies identify distinct groups of FGFs that are differentially expressed and suggest active stage‐specific roles for FGF signaling during the fracture repair process. Developmental Dynamics 238:766–774, 2009. © 2009 Wiley‐Liss, Inc.