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Tendons and muscles of the mouse forelimb during embryonic development
Author(s) -
Watson Spences S.,
Riordan Timothy J.,
Pryce Brian A.,
Schweitzer Ronen
Publication year - 2009
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.21866
Subject(s) - forelimb , biology , anatomy , tendon , hindlimb , transverse plane , embryo , embryogenesis , process (computing) , microbiology and biotechnology , computer science , operating system
Abstract The range and precision of limb movements are dependent on the specific patterns of muscles and tendons. To facilitate analyses of tendon and muscle phenotypes we compiled a description of these tissues in the forelimb of developing mouse embryos. Individual tendons, muscles, and ligaments were annotated in a series of transverse sections through the forelimb of an embryo at day 18.5 of embryonic development (E18.5). Transverse sections present a distinctive and highly reproducible pattern of the muscles and tendons at different limb levels that can be used as a simple reference in analyses of mutant phenotypes. A comparable set of sections from an embryo at E14.5 was included to highlight structural features that change during the maturation of the musculoskeletal system. The ability to define the precise position of transverse sections along the proximal–distal axis of the limb may also be useful in studies of other features in developing limbs. Developmental Dynamics 238:693–700, 2009. © 2009 Wiley‐Liss, Inc.