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VEGF‐mediated fusion in the generation of uniluminal vascular spheroids
Author(s) -
Gentile Carmine,
Fleming Paul A.,
Mironov Vladimir,
Argraves Kelley M.,
Argraves W. Scott,
Drake Christopher J.
Publication year - 2008
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.21825
Subject(s) - spheroid , biology , vegf receptors , fusion , microbiology and biotechnology , biophysics , anatomy , cancer research , biochemistry , in vitro , linguistics , philosophy
VEGF‐mediated vascular fusion in the generation of uniluminal spheroids. Luminized vascular networks present in mouse allantoic‐derived tissue spheroids (upper image) fuse when treated with VEGF to form a single central vessel (lower image). Spheroids were immunolabeled with antibodies to PECAM‐1 (green) and SMαA (red). See Gentile et al., Developmental Dynamics 237:2918–2925. Developmental Dynamics 237:2918–2925, 2008. © 2008 Wiley‐Liss, Inc.