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Diverse expression patterns of LIM‐homeodomain transcription factors (LIM‐HDs) in mammalian inner ear development
Author(s) -
Huang Mingqian,
Sage Cyrille,
Li Huawei,
Xiang Mengquig,
Heller Stefan,
Chen ZhengYi
Publication year - 2008
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.21735
Subject(s) - biology , homeobox , inner ear , transcription factor , lim domain , microbiology and biotechnology , emx2 , zinc finger , anatomy , genetics , gene
Abstract LIM‐homeodomain transcription factors (LIM‐HDs) are essential in tissue patterning and differentiation. But their expression patterns in the inner ear are largely unknown. Here we report on a study of twelve LIM‐HDs, by their tempo‐spatial patterns that imply distinct yet overlapping roles, in the developing mouse inner ear. Expression of Lmx1a and Isl1 begins in the otocyst stage, with Lmx1a exclusively in the non‐sensory and Isl1 in the prosensory epithelia. The second wave of expression at E12.5 includes Lhx3, 5, 9, Isl2 , and Lmx1b in the differentiating sensory epithelia with cellular specificities. With the exception of Lmx1a and Lhx3 , all LIM‐HDs are expressed in ganglion neurons. Expression of multiple LIM‐HDs within a cell type suggests their redundant function. Developmental Dynamics 237:3305–3312, 2008. © 2008 Wiley‐Liss, Inc.