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Drosophila SIN3 is required at multiple stages of development
Author(s) -
Sharma Vishal,
Swaminathan Aishwarya,
Bao Riyue,
Pile Lori A.
Publication year - 2008
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.21706
Subject(s) - biology , gene isoform , histone deacetylase , drosophila melanogaster , microbiology and biotechnology , psychological repression , transcription factor , transcription (linguistics) , genetics , histone , gene expression , gene , linguistics , philosophy
SIN3 is a component of a histone deacetylase complex known to be important for transcription repression. While multiple isoforms of SIN3 have been reported, little is known about their relative expression or role in development. Using a combination of techniques, we have determined that SIN3 is expressed throughout the Drosophila life cycle. The pattern of expression for each individual isoform, however, is distinct. Knock down of all SIN3 expression reveals a requirement for this protein in embryonic and larval periods. Taken together, the data suggest that SIN3 is required for multiple developmental events during the Drosophila life cycle. Developmental Dynamics 237:3040–3050, 2008. © 2008 Wiley‐Liss, Inc.