Premium
Fishing lines, time‐delayed guideposts, and other tricks used by developing pharyngeal neurons in Caenorhabditis elegans
Author(s) -
Pilon Marc
Publication year - 2008
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.21636
Subject(s) - biology , caenorhabditis elegans , caenorhabditis , neuroscience , pharynx , anatomy , genetics , gene
The 20 neurons that innervate the Caenorhabditis elegans pharynx form a simple nervous system that develops and operates in near complete isolation from the rest of the worm body and, therefore, offers a manageable degree of complexity for developmental genetics studies. This review discusses the progress that has been made in determining the mechanisms by which 4 of the 20 pharyngeal neurons develop, and emphasizes surprising processes that add to the classic growth cone guidance model which is usually thought to explain how most axons establish their trajectories. Developmental Dynamics 237:2073–2080, 2008. © 2008 Wiley‐Liss, Inc.