WNT signaling affects gene expression in the ventral diencephalon and pituitary gland growth | Zendy

Potok Mary Anne | Zendy; Cha Kelly B. | Zendy; Hunt Andrea | Zendy; Brinkmeier Michelle L. | Zendy; Leitges Michael | Zendy; Kispert Andreas | Zendy; Camper Sally A. | Zendy

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WNT signaling affects gene expression in the ventral diencephalon and pituitary gland growth

Author(s) -

Potok Mary Anne,

Cha Kelly B.,

Hunt Andrea,

Brinkmeier Michelle L.,

Leitges Michael,

Kispert Andreas,

Camper Sally A.

Publication year - 2008

Publication title -

developmental dynamics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.634

H-Index - 141

eISSN - 1097-0177

pISSN - 1058-8388

DOI - 10.1002/dvdy.21603

Subject(s) - biology , diencephalon , pituitary gland , ectopic expression , endocrinology , lobe , anatomy , mutant , immunohistochemistry , medicine , microbiology and biotechnology , gene , hypothalamus , hormone , immunology , biochemistry

WNT5A deficiency causes pituitary dysmorphology and ectopic melanotrope differentiation. Immunohistochemistry for prohormone convertase 2 (PC2) marks melanotrope cells, which are normally confined to the intermediate lobe of the pituitary gland. Wnt5a mutant mice contain ectopic melanotropes in a region of dysmorphology adjacent to the intermediate lobe. We show a coronal section from an e18.5 Wnt5a mutant pituitary gland stained with a PC2 specific antibody, developed with the chromagen diaminobenzidine, and counterstained with hematoxylin. The image is artistically arranged as a mirror image duplication with the dorsal aspect of the pituitary facing the outer edges and the ventral aspect towards the center plane. See Potok et al., Developmental Dynamics 237:1006–1020, 2008. © 2008 Wiley‐Liss, Inc.

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