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VAMP2 is expressed in myogenic cells during rat development
Author(s) -
Tajika Yuki,
Murakami Tohru,
Sato Mahito,
Kubota Fumitaka,
Yorifuji Hiroshi
Publication year - 2008
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.21596
Subject(s) - biology , myogenesis , myotome , skeletal muscle , myocyte , myogenic regulatory factors , microbiology and biotechnology , anatomy , somite , endocrinology , medicine , embryo , embryogenesis , myogenin
Vesicle‐associated membrane protein 2 (VAMP2) is a member of the SNARE family of proteins that regulate the intracellular vesicle fusion process. This study investigated the developmental expression of VAMP2 in the rat embryo. In the trunk, VAMP2 was primarily found in the heart on embryonic day (E) 10. On E12.5, VAMP2 expression was found in nerve fibers, somites, and heart. In somites, epithelial cells in the dorsomedial lip, and elongated myoblasts in myotome were positive for VAMP2. On E16.5, VAMP2 was expressed in the heart, nerve fibers, and skeletal muscles. In skeletal muscles, multinuclear myotubes were positive for VAMP2. In the head, where muscles are derived both from somitic and non‐somitic origin, VAMP2 was found in myotubes of the extrinsic ocular muscles and masseter muscle on E16.5. These findings suggest the involvement of VAMP2 in the development of skeletal muscles of somitic and non‐somitic origins. Developmental Dynamics 237:1886–1892, 2008. © 2008 Wiley‐Liss, Inc.