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Influence of Hormones and Hormone Metabolites on the Growth of Schwann Cells Derived From Embryonic Stem Cells and on Tumor Cell Lines Expressing Variable Levels of Neurofibromin
Author(s) -
Roth Therese M.,
Ramamurthy Poornapriya,
Muir David,
Wallace Margaret R.,
Zhu Yuan,
Chang Lou,
Barald Kate F.
Publication year - 2008
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.21537
Subject(s) - biology , dapi , schwann cell , staining , neurofibroma , embryonic stem cell , plexiform neurofibroma , stem cell , microbiology and biotechnology , cell culture , cancer research , biochemistry , neurofibromatosis , genetics , gene
A benign human plexiform neurofibroma cell. Note the extensive tubulin networks (red), which become disrupted after addition of 2ME2, an estrogen metabolite implicated in tumor toxicity. The green staining represents S100 staining, indicating the Schwann Cell origin of the tumor cells. Blue is DAPI nuclear staining. See Roth et al., Developmental Dynamics 237:513–524, 2008. © 2008 Wiley‐Liss, Inc.