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Expression of the NET family member Zfp503 is regulated by hedgehog and BMP signaling in the limb
Author(s) -
McGlinn Edwina,
Richman Joy M.,
Metzis Vicki,
Town Liam,
Butterfield Natalie C.,
Wainwright Brandon J.,
Wicking Carol
Publication year - 2008
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.21508
Subject(s) - gli3 , biology , limb bud , zebrafish , limb development , hedgehog , sonic hedgehog , bone morphogenetic protein , microbiology and biotechnology , transcription factor , hedgehog signaling pathway , genetics , zinc finger , signal transduction , zone of polarizing activity , apical ectodermal ridge , homeobox , mesoderm , gene , repressor , embryonic stem cell
The NET/Nlz family of zinc finger transcription factors contribute to aspects of developmental growth and patterning across evolutionarily diverse species. To date, however, these molecules remain largely uncharacterized in mouse and chick. We previously reported that limb bud expression of Zfp503 , the mouse orthologue of zebrafish nlz2 / znf503 , is dependent on Gli3. Here, we show that Zfp503 / Znf503 is expressed in a restricted pattern during mouse and chick embryogenesis, with particularly dynamic expression in the developing limbs, face, somites, and brain. We also add to our previous data on Gli3 regulation by showing that the anterior domain of Zfp503 expression in the mouse limb is responsive to genetic and nongenetic manipulation of hedgehog signaling. Finally, we demonstrate that posterior expression of Znf503 in the chick limb is responsive to bone morphogenetic protein (BMP) signaling, indicating that Zfp503 / Znf503 may act at the nexus of multiple signaling pathways in development. Developmental Dynamics 237:1172–1182, 2008. © 2008 Wiley‐Liss, Inc.