Premium
Expression of ERK signaling inhibitors Dusp6 , Dusp7 , and Dusp9 during mouse ear development
Author(s) -
Urness Lisa D.,
Li Chaoying,
Wang Xiaofen,
Mansour Suzanne L.
Publication year - 2008
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.21380
Subject(s) - biology , mapk/erk pathway , dusp6 , fibroblast growth factor , microbiology and biotechnology , phosphatase , kinase , signal transduction , fgf and mesoderm formation , extracellular , phosphorylation , protein phosphatase 2 , embryogenesis , genetics , embryo , receptor , ectoderm
The levels of fibroblast growth factor (FGF) signaling play important roles in coordinating development of the mouse inner, middle, and outer ears. Extracellular signal‐regulated kinases (ERKs) are among the effectors that transduce the FGF signal to the nucleus and other cellular compartments. Attenuation of ERK activity by dephosphorylation is necessary to modulate the magnitude and duration of the FGF signal. Recently, we showed that inactivation of the ERK phosphatase, dual specificity phosphatase 6 (DUSP6), causes partially penetrant postnatal lethality, hearing loss and skeletal malformations. To determine whether other Dusp s may function redundantly with Dusp6 during otic development, we surveyed the expression domains of the three ERK‐specific DUSP transcripts, Dusp6 , Dusp7 , and Dusp9 , in the embryonic mouse ear. We show that each is expressed in partially overlapping patterns that correspond to regions of active FGF signaling, suggesting combinatorial roles in negative regulation of this pathway during ear development. Developmental Dynamics 237:163–169, 2008. © 2007 Wiley‐Liss, Inc.