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Differential growth and multicellular villi direct proepicardial translocation to the developing mouse heart
Author(s) -
Rodgers Laurel S.,
Lalani Sofia,
Runyan Ray B.,
Camenisch Todd D.
Publication year - 2008
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.21378
Subject(s) - biology , multicellular organism , microbiology and biotechnology , chromosomal translocation , anatomy , endocardium , mesothelium , genetics , medicine , cell , peritoneum , gene
In the mammalian system the proepicardium (PE) arises from mesothelium of the septum transversum before translocation to the heart where it forms the epicardium and progenitor cells of the coronary vessels. Despite its importance, the process in which PE cells translocate to the myocardium in mammals is not well defined. The current paradigm states that cellular cysts of PE float across the pericardial space and contact the outer surface of the myocardium. This mechanism does not provide a satisfactory explanation for the directionality or localization of PE migration. To better define PE migration, we performed a detailed study of mouse PE development. We provide thorough documentation that redefines the size of the PE migratory field and the mechanism of migration. Our new model incorporates differential growth and direct contact between multicellular PE villi and the myocardium as mechanisms in formation of the epicardium. Developmental Dynamics 237:145–152, 2008. © 2007 Wiley‐Liss, Inc.