Premium
Early embryonic expression patterns of the mouse Flamingo and Prickle orthologues
Author(s) -
Crompton Lucy A.,
Du Roure Camille,
Rodriguez Tristan A.
Publication year - 2007
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.21338
Subject(s) - biology , gastrulation , endoderm , ectoderm , primitive streak , mesoderm , neuroectoderm , microbiology and biotechnology , genetics , intermediate mesoderm , epiblast , ingression , embryonic stem cell , embryogenesis , embryo , gene
The Drosophila melanogaster proteins Flamingo and Prickle act in the planar cell polarity (PCP) pathway, which is required for acquisition of epithelial polarity in the wing, eye, and epidermis. In mammals, PCP signaling has been shown to regulate cell movements and polarity in a variety of tissues. Here, we show that the murine Flamingo orthologues Celsr1–3 and the Prickle orthologues Prickle1, Prickle2 , and Testin have dynamic patterns of expression during pregastrulation and gastrulation stages. Celsr1 is expressed in the anterior visceral endoderm and nascent mesoderm, Celsr2 and Celsr3 mark the prospective neuroectoderm, Prickle1 is expressed in the primitive streak and mesoderm, Prickle2 in the node, and Testin in the anterior visceral endoderm, the extraembryonic ectoderm, primitive streak, and mesoderm. Analysis of a gene‐trap mutation in Testin indicates that this gene is not required for embryogenesis; therefore, other Prickle homologues may compensate for its function during development. Developmental Dynamics 236:3137–3143, 2007. © 2007 Wiley‐Liss, Inc.